Thiazide diuretics, like hydrochlorothiazide; triamterene, are contraindicated in patients with known thiazide diuretic hypersensitivity. According to the manufacturer, hydrochlorothiazide is specifically contraindicated in patients with sulfonamide hypersensitivity. Information on captopril (Capoten), and ACE inhibitor prescriped for the treatment of high blood pressure, heart failure, kidney failure prevention due to high blood pressure and diabetes. Medical uses. Hydrochlorothiazide is frequently used for the treatment of hypertension, congestive heart failure, symptomatic edema, diabetes insipidus, renal tubular acidosis. It is also used for the prevention of kidney stones in those who have high levels of calcium in their urine. Lisinopril/hydrochlorothiazide, sold under the trade name Zestoretic among others, is a combination of the medications lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. It is used to treat high blood pressure. Typically it becomes an option once a person is doing well on the individual components. It is taken by mouth. Etude ELITE Evaluation of losartan in the elderly study LANCET saturday 15 larch 1997 Vol. 349 N°.9054 Page 747-752 Etude comparative versus captopril chez des patients 65 ans avec une insuffisance cardiaque congestive (systolic left-ventricular dysfunction ) Traitement de l'hypertension artérielle essentielle. Cette association à dose fixe est indiquée chez les patients dont la pression artérielle n'est pas suffisamment contrôlée par le captopril seul ou l'hydrochlorothiazide seul. Captopril is a white to off-white crystalline powder that may have a slight sulfurous odor; it is soluble in water (approx. 160 mg/mL), methanol, and ethanol and sparingly soluble in chloroform and ethyl acetate. DESCRIPTION. CAPOTEN® (captopril tablets, USP) is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II. Captopril dosing information. Usual Adult Dose for Hypertension: Initial dose: 25 mg orally 2 to 3 times a day one hour before meals Maintenance dose: May increase every 1 to 2 weeks up to 50 mg orally three times a day. Initially, 1 tablet bisoprolol; hydrochlorothiazide 2.5 mg/6.25 mg PO once daily. Titrate dosage every 2 weeks up to the maximum dosage based on clinical response.